Objective:To study the clinical features of second primary pancreatic cancer(PC).Methods:The clinical features of 32 cases pathologically diagnosed second primary PC were retrospectively analyzed in detail,and 96 cases of common primary PC were taken as control.Results:Among 32 second primary PC patients, 15(46.9％) occurred after breast cancer or gastric cancer.Of sex,age,location of neoplasms,clinical symptoms,routine laboratory tests and assay of tumor markers,there were no significant differences between second primary PC and primary PC; only the age was a little younger than that of common PC; the percentage of dyspepsia was slightly higher;the percentages of abdominal pain and jaundice were slightly lower.The sensitivities of abdominal ultrasonography,spiral computed tomography(SCT),magnetic resonance imaging(MRI) and endoscopic retrograde cholangiopancreatography(ERCP) in diagnosis of second primary PC were higher than that of common PC.Only 2 patients(6.3％) were in stage Ⅰ.The total half-year survival rate was 52.0％ for second primary PC,which was lower than that of common PC.Conclusion:The symptoms of second primary PC are more atypical than that of common PC,so the diagnosis is more difficult,and the prognosis is even worse.We should pay more attention to the studies of early detection measures(such as tumor markers) associated with the first primary cancers.