Objective：To study the outcomes of a modified cavoportal hemitransposition technique for liver transplantation in treatment of diffuse portal vein thrombosis. Methods： Two patients with diffuse portal vein thrombosis received liver transplantation by modified cavoportal hemitransposition. Anastomosis between the native inferior vena cava and the graft coeliomesenteric vein and adjuvant anastomosis between the native portal vein and graft spleen vein were performed to reconstruct the blood flow of portal vein. The post-operation liver function, portal flow, renal insufficiency, edema of lower extremities, and the varices of esophagus or gastric fundus were observed. Results： The operation was successful in both cases, with normal post-operation liver function and satisfactory portal flow. There was no complication such as renal insufficiency, edema of lower extremities, and varices of esophagus or gastric fundus. Conclusion： This modified cavoportal hemitransposition technique in liver transplantation is proved effective for diffuse portal vein thrombosis.