Objective：To compare the anti-aging effects of ginsenosides,tanshinone and chuanxionyzine on the skin of D-galactose-induced mice aging model. Methods.. One hundred female mice were randomly d[vided into 5 groups（n= 20）. Mice in normal control group received subcutaneous injection of normal saline and mice in other 4 groups received cervicodorsal injection of D-galactose （1 000 mg·kg^-1·d^-1 ） for 42 d to establish subacute aging model. The experimental groups included aging model group （without further treatment）, tanshinone-treated （1 500 mg·kg^-1·d^-1） group,chuanxionyzine-treated （150 mg·kg^-1·d^-1） group,and ginsenosides-treated （100 mg·kg^-1·d^-1） group. Forty two days later,the dorsal skin samples were collected to determine SOD,CAT activities and MDA,hydroxyproline contents. Results： In tanshinone- and ginsenosides-treated groups,SOD activities increased from （131.2±21.5） U/ml to （203.1 ±11.2） U/ml and （196.8±27.5） U/ml,respectively; the contents of hydroxyprolin increased from （0.57±0.13） mg/g to （0.71±0.11） mg/g and （0.76±0.12） mg/g,respectively; and the contents of MDA decreased from （9.39± 1.5） nmol/g to （6.4±1.3） nmol/g and （7.16 ± 2.3） nmol/g, respectively （all P〈0.05）. However, there was no significant difference between the parameters of tanshinone- and ginsenosides-treated groups. Compared with aging control group, there was no obvious changes in the above parameters in chuanxionyzine-treated group. Conclusion： Both ginsenosides [100 mg/（kg ·d） ]and tanshinone [1 500 mg/（kg ± d）] have noticeable anti-skin aging effects via i.g. administration through improving the activities of antioxidant enzyme and dermal fibroblasts. Chuanxionyzine [150 mg/（kg · d）] shows no anti-skin aging effects in mouse aging models.