Objeetive..To investigate the effect of high-volume hemofiltration （HVHF） on serum levels of IL-6 and pulmonary expression of IL-6 mRNA in pigs with multiple organ dysfunction syndrome （MODS）. Methods： Twenty-five pigs were randomly divided into model group, control group and HVHF group. Animals in control group were injected with normal saline, and those in the other 2 groups were treated with ＂a second hit＂ to establish MODS model, then animals in HVHF group was treated with HVHF for 3 days. Serum IL-6 levels were determined by ELISA and Real-time quantitative PCR was used to determine the expression level of IL-6mRNA. Lymphocyte apoptosis was detected by Annexin-V/PI flow cytometry. Results： After HVHF, the serum indices associated with organ-function and the morbidity and mortality were much lower than those in MODS model group （P〈0.05）. The expression level of IL-6 mRNA in lung was reduced significantly in HVHF group com- pared with that in model group （P〈0.05）; moreover, the lymphocyte apoptosis rate was also significantly decreased compared with model group （P〈0.01）. Conclusion.. Early HVHF can decrease the high serum levels of IL-6 and the over-expression of IL-6 mRNA in lungs caused by trauma; it can also decrease the lymphocyte apoptosis rate, so as to prevent the incidence of lung failure