Objective：To investigate the relationship between HLA-DRB alleles and primary biliary cirrhosis (PBC) in patients living in northern China. Methods: The HLA-DR genes of 40 PBC patients and 67 healthy controls were genotyped by using DNA microarray technique. The subjects in the 2 groups were matchable in their ages and gender ratios. Results: The frequency of HLA-DR7 was 50% in PBC patients, which was significantly higher than that of healthy controls (10.4%) (χ=20.77,P=0.000,RR=8.57) and those reported in another 2 literatures (23.2%, \[N=342, P=0.000\] and 29%, \[N=255, P=0.008\]). The frequency of HLA-DR8 was 22.5% in PBC patients, which was significantly higher than that of healthy controls (7.5%,\[χ=4.980,P=0.026,RR=3.60\]) and those reported in the other 2 literatures (11.2%, \[N=342, P=0.038\] and 10.2%, \[N=255, P=0.025\]). Conclusion: It is suggested that the morbidity of PBC in northern Chinese citizens is associated with HLA-DR7 and DR8. DR7 has not been reported in literatures outside China.