In modern war,psychotropic drugs,including central stimulants and central depressants,have profound influence on the mental states of soldiers.This paper reviews the pharmacokinetics,pharmacological mechanisms and efficacy of psychotropic drugs;and also introduces the application of psychotropic drugs for sleep regulation and anti-fatigue in aircrew members during Iraqi war,South Atlantic Campaign,Libyan Air Strike and Gulf War.Suggestions are given on proper use of psychotropic drugs in wartime.