In recent years, drug resistance of Candida albicans is on a rise in clinical practice. Gene chip technique is the most commonly used means to map gene expression profile in drug resistant Candida albicans. Gene chip can be used to analyze the differentially expressed genes in drug resistant Candida albicans strains induced by various procedures. The drug resistant genes can be identified and their functions can be further studies. The results of gene chip study can also play a role in studying the mechanism of synergism of multiple drug resistance genes.