Oxidative stress is a major cause of fatty liver,atherosclerosis,cancer,organ damage following ischemia/reperfusion,etc.In recent years,significant improvements have been achieved in studies on signaling pathways involved in oxidative stress,which provide a basis for the drug and gene therapy.This article reviews the major redox-related signaling molecules and pathways,including transcription factors,growth factor signaling,tyrosine kinases and serine/threonine kinases.