Objective：To evaluate the validity and reliability of adapted simplified Chinese Version of the Scoliosis Research Society-22 (SRS-22) questionnaire. Methods: The English version of the SRS-22 was translated into simplified Chinese and was subjected to cross-culture adaptation; the final version of the simplified Chinese SRS-22 questionnaire was a consensus reached by an expert committee. Then the simplified Chinese version SRS-22 questionnaire and 36Item Short Form Health Survey (MOS SF-36) questionnaire were used to survey 87 patients with adolescent idiopathic scoliosis who had been surgically treated; 63 patients （72.4％） responded to the SRS-22 questionnaire. The average age of these patients (6 male, 57 female) was (17.7±3.1) years (range, 14.3-23.8 years). Fifty-six of the 63 patients returned the MOS SF-36 questionnaire. The 2 indicators of reliability were Cronbach’s α of internal consistency and intraclass correlation coefficient（ICC）. Concurrent validity of the SRS-22 questionnaire was measured by comparing with domains of the SF-36 questionnaire, which was reflected by Pearson correlation coefficient (r). Results: The Cronbach α values for 4 domains (function/activity，pain，self-image/appearance, and mental health) were all higher than 0.7; and the Cronbach α value for satisfaction of management domain was acceptable. The intraclass correlation coefficients for function/activity，pain，self-image/appearance, mental health, and satisfaction domain were 0.74, 0.78, 0.86, 0.81 and 0.84, respectively, demonstrating a satisfactory reproducibility. For the concurrent validity, 3 domains had excellent correlation, 10 had good correlation, and 21 had moderate correlation. Conclusion: The adapted simplified Chinese Version of the SRS-22 questionnaire has satisfactory reliability and concurrent validity, and might be suitable for post-operation clinical evaluation of Chinese adolescent patients with scoliosis.