Objective：To study the influence of anti-tumor drug incorporation on the physicochemical properties of calcium phosphate cement（CPC）. Methods： Methotrexate （MTX）, epirubicin （EPI）, hydroxy camptothecin （OH-CPT）, and arsenic trioxide （As2O3） were incorporated, each in a proportion of 2%, 5 %, and 8%, into the powder-phase CPC. Untreated CPC was taken as control. The setting time, compression strength, and the microstructure of the resultant products were evaluated and tested. Results： Compared with control group, the setting time was significantly prolonged when 2 % EPI was incorporated into CPC （P〈0.05）, and the maximum compression strength was significantly decreased when 5% OH-CPT and 8% MTX, EPI were incorporated into CPC （P〈0.05）. Electron microscope showed no significant change in the crystal structure after incorporation of the drugs. Conclusion： CPC is an ideal anti-tumor drug delivery material. The changes of physicochemical properties of CPC must be considered when anti-tumor drugs are incorporated into CPC for clinical application.[