Objectlve：To assess the clinical outcome of autologous fat injection in treatment of hemifacial atrophy, so as to search for an ideal treatment of hemifacial atrophy. Methods： Autologous fat granules were obtained by tumescent liposuction. After purification, the fat granules were injected in a multi-strata, multi-tunnel, and multi-spot manner to repair facial introcession abnormality. Patients whose introcession was not improved after the stabilization of the fillings were re-injected with autologous fat granules twice or more until satisfactory outcomes were achieved. Results： All the 7 patients in this study obtained satisfactory outcomes after fat injection and basically reached symmetry. The follow-up result was good after 2 years. Conclusion： Local injection transplantation of autologous fat granules is effective for the treatment of facial depression and hemifacial atrophy, with slight trauma, little complication, and satisfactory outcome.[