Objective：To investigate the effect of arterial baroreflex （ABR） on survival rate of rats with cecal ligation and puncture （CLP）-induced sepsis. Methods： Male Sprague -Dawley rats were divided into 2 groups., sham-operated rats （n=22） and sinoaortic denervated （SAD） rats （n= 22）. Four weeks after SAD rats were subjected to CLP-induced sepsis, the blood pressure and heart period （HP） were monitored for 12 hours in conscious state and the survival of rats was observed. Results.. Both the diastolic and systolic blood pressue gradually decreased after CLP. the HP shortened first and then drastically prolonged until the death of rats. At 12 h after CLP the survival rate of SAD rats was lower than that of the sham operated rats （59 % vs 86%）. Significant differences were found between the Kaplan-Meier survival curves of the rats in 2 groups（P〈0.05）. Conclusion： ABR plays an important role in CLP-induced lethal sepsis model