Objective：To compare the influences of onychomycosis on quality of life between patients from Luoyang and Shanghai. Methods: A semi-structured questionnaire was used to analyze and compare the influences of onychomycosis on the quality of life of patients from Luoyang and Shanghai. Results: Ninety-six patients with onycomycosis were from Luoyang district, including 41(42.7%) males and 55 (57.3%) females. One hundred and eighteen patients were from Shanghai, including 52 (44.1%) males and 66 (55.9%) females. Onychomycosis had more severe influences on patients living in Luoyang than those living in Shanghai from the following 4 perspectives: subjective health feeling, emotional influence, thinking influence, and social communication difficulties. Onychomycosis had greater influence on patients who aged 41-50 years old, who had a disease course of 1-5 years, and who had a higher academic background. Conclusion:The influences of onychomycosis on quality of life are different for patients with different economic, cultural backgrounds.