Objective:To explore the surgical techniques of liver transplantation(LT)for a hepatic cancer patient with complete situs inversus (CSI) and to discuss the post-operation management of complications.Methods: A patient with CSI suffering from hepatocelluar carcinoma underwent LT in June 2005.LT was performed orthotopically using the clockwise 90° rotation technique with all vessels end-to-end anastomized.The post-operation complications were actively managed and the patient was followed up.Results: Post-operatively,the patient recovered well without major complications,except for a bile duct anastomotic stenosis during the 5th post-operative month,which was dealt with endoscopic retrograde biliary drainage and percutaneous transhepatic cholangial drainage.Liver function was stable and no tumor recurrence was found during a follow-up period of 30 months.Conclusion: It is feasible to perform LT in patients with CSI.Bile duct anastomotic stenosis is one of the most important complications after LT,which can have a good long-term prognosis if promptly managed.