Toumor microenvironment is closely related to the development and progression of tumors.Recently, researchers suggest that abnormal differentiation of stem cells might lead to the initiation of cancer.Microenvironment is the key to homeostatic regulation of stem cells.Disregulation of microenvironment plays an important role in the carcinogenesis.And during the development of tumor,a suitable microenvironment can promote the rapid proliferation of tumor.Changing the specific microenvironment can suppress the tumorigenic phenotype of aggressive cancer.Meanwhile,microenvironment also plays an essential role in cancer metastasis.Understanding of these underlying mechanisms will enhance our knowledge of cancer and will provide a novel basis for prevention and treatment of cancer..