Objective:To observe the effect of ultrasound ablation combined with the balloon angioplasty in treatment of patients with arteriosclerosis obliteration of lower extremity and diabetic foot.Methods: The 60 limbs of 47 patients with arteriosclerosis obliteration of lower extremity (AOLE) were treated comprehensively by anti-infection,enlarging blood vessel,improving circulation,and anticoagulation; they also received ultrasound ablation,balloon angioplasty and stenting.Results: The patent rate of the 60 limbs was 93.3%.One month and 3 months after treatment with ultrasound ablation combined with balloon angioplasty,the MRI of artery of lower extremity,ultrasound manifestation,ankle-brachial index (ABI),the skin temperature of lower extremity and the sense to coolness,numbness,pain,ochrodermia or cyanosed were all improved to some extents compared with those before treatment.The healing of the diabetic foot was also accelerated.Conclusion: Ultrasound ablation combined with the balloon angioplasty and stenting,together with conventional treatment like anti-infection,anticoagulation,enlarging blood vessel,improving circulation,can reopen the occluded blood vessels and improve blood supply,thus provides a favourable condition for treatment of diabetic foot.