Objective:To study the clinical features and prognostic factors of bone metastases of non-small-cell lung cancer.Methods: The clinical data of 174 patients with bone metastases of non-small-cell lung cancer,who were treated in our hospital during April 1999 to June 2006,were retrospectively analyzed.Kaplan-Meier analysis was used to estimate the 1- and 2-year survival rates of patients.Log-rank test was used to screen the factors influencing the survival of patients and Cox regression was used to further confirm the independent factors.Results: The predilection sites of bone metastases of non-small-cell lung cancer were chest (38.1%),spine (32.8%),pelvis (16.3%),extremities (8.7%),and skull (4.1%),with the ribs (30.7%),lumber vertebrae (17.3%),and thoracic vertebra (13.1%) ranking the top three.The median survival time of the 174 patients was 10.73 months; Kaplan-Meier analysis showed that the 1- and 2-year survival rates were 47.1% and 17.8%,respectively.It was also showed that the PS Score,bone pain,asymptomatic bone metastases,solitary bone metastasis,serum AKP,LDH,and CEA were associated with the prognosis of patients (P<0.05).Multivariate analysis showed that PS score,solitary bone metastasis and single bone metastasis were the independent factors of prognosis.Conclusion: The predilection sites of bone metastasis of non-small-cell lung cancer include chest part (ribs),spine (lumber/thoracic vertebrae),pelvis (ilium),etc.PS score,asymptomatic bone metastases,and solitary bone metastasis have great influence on the prognoses of patients.