Objective:To study the transurethral endoscopic approach for removal of seminal vesical stone and to evaluate its efficacy.Methods: The diagnosis of 18 patients with seminal vesicle stones were confirmed by ultrasonography,X-ray or computerized tomography before operation.The patients,with a mean age of (41.5±5.3) years old and a mean disease course of (6.6±3.6) months,included 15 with intractable hemospermia,3 with perineal discomfort and 2 with painful ejaculation.Seminal vesical stones were found unilaterally in 16 cases and bilaterally in 2 cases.We passed a 6/7.5F rigid urethroscope through the utricular opening into the seminal vesicle,and all the stones in 17 patients were endoscopically removed using a grasper; one patient was treated by holmium-laser due to the large size of the stones.Results: The mean operation period was （35.6±13.4）min and the mean hospital stay was (4.1±1.5) days.The mean follow-up period was (6.4±3.1) months.Hematospermia disappeared in 15 (15/15) cases after treatment; painful ejaculation disappeared in 2(2/2) cases and perineal discomfort was improved in 2(2/3) cases.One patient had epididymitis a week after the operation and the symptoms were relieved after 5-day-antibiotic therapy.Conclusion: Transurethral endoscopic approach for treatment of seminal vesicle stone has a better outcome,less trauma and few complications; it is an effective method for seminal vesicle stone removal.