Severe burns and trauma can lead to insulin resistance (IR), which is associated with the metabolic disorder and hyperglycemia, and routine insulin treatment yield no noticeable outcome. However, long time bigdose insulin treatment can sometimes cause hypoglycemia, threatening the life of patients and making the condition more complicated to treat. By now, the mechanism of IR is not yet clearly understood. This article reviews the recent researches about the postreceptor signal transduction mechanism of IR after severe burns and its influencing factors.