Objective To explore the feasibility of repairing opposite side ventriplanta soft tissue defects with the medial plantar artery combined flaps with saphenous nerve.Methods From Jan. 2007 to Apr. 2009, 12 patients with opposite side ventriplanta soft tissue defects were repaired using the medial plantar artery combined flaps with saphenous nerve. Five cases used cross leg flaps, and 7 cases used free skin flaps. All the cases were men, with an age range of 640 years (only one child case). The sizes of flaps were 12 cm × 7 cm13 cm×8 cm for adults and 8.5 cm×6 cm for child. The pedicles of cross leg flaps were cut off after 34 weeks.Results All the 12 flaps survived. The patients were followed up for 6 months to 1 year. The color，texture and appearance of the flaps were satisfactory．The flaps of the two point discrimination were 69 mm on ventriplanta of reconstruction, and the affected limb could exercise freely, without ulcer on the flap.Conclusion The medial plantar artery combined flaps with saphenous nerve can be used to repair opposite side ventriplanta vast soft tissue defects, with large flap and good texture, appearance. It can effectively recover the two point discrimination, but it has a complicated protocal.