\[Abstract\]Candida albicans, the most common fungal pathogen, can cause mucosal and systemic infections. Until now there are only a limited number of antifungal drugs, and long-term repeated use of the existing drugs has led to rapid development of drug resistance. The high adaptability of C. albicans has led to drug resistance, which is also a manifestation of environmental stress of C. albicans to the environment. This article summarizes the response pathways of C. albicans stress and describes drug resistance of C. albicans from the aspect of stress response.