ObjectiveTo summarize our experience on laparoscopic radical prostatectomy via single incision in treatment of early localized prostate cancer.MethodsFrom June 2009 to August 2009,five patients with localized prostate cancer（T1c）received laparoscopic radical prostatectomy via single incision.A home-made multichannel port was inserted extraperitoneally through a 3 cm incision under the umbilicus.A 10 mm TROCAR and two 5 mm TROCAR were inserted.The prostate was isolated and excised,then the bladder urethral anastomosis was performed.ResultsThe procedures were successful in all the five cases with no transversion to open or standard laparoscopic approach.The mean operating time,the mean operative time for prostate excision,and the mean time for urethrovesical anastomosis were (167±31.5) min(ranging 135-210 min),(115±26) min (ranging 90-150 min),and (52±5.7) min(ranging 45-60 min),respectively.The estimated blood loss averaged (90±62) ml (ranging 50-200 ml).Positive margin occurred in one case.Transient incontinence occurred in two cases after the catheter was removed one week later.All patients had a prostate-special antigen level ＜0.2 μg/L during a follow-up of 4-12 weeks.ConclusionLaparoscopic radical prostatectomy via single incision is feasible and safety.Excellent instruments and skilled surgeon are the keys for the success of the operation.