\[Abstract\]Danger associated molecular pattern(DAMPs) is defined as the danger signal molecules that can be recognized by pattern recognition receptors (PRRs).High-mobility group box 1 protein (HMGB1) belongs to DAMPs and the release of HMGB1 indicates the damage of tissues.Many researches have showed that HMGB1 participates in tumor angiogenesis,evasion of apoptosis,self-sufficiency in growth signals and invasion and metastasis,indicating HMGB1 can promote tumor development and progression.More recent findings indicate that HMGB1 can be used as an adjuvant to enhance the efficiency of the antitumor immune response.Various reports have suggested that HMGB1 plays a double phase action in tumor immunological regulation.This papers is aimed to review the role of HMGB1 in tumor immunological regulation and the related mechanisms.