ObjectiveTo examine the influence of ascorbic acid supplementation on mouse model of Candida albicans infection.MethodsMouse models of systemic Candida albicans infection were established by the tail vein injection of Candida albicans suspension and were randomly divided into five groups (n=10).Ascorbic acid was administered by gavage or intraperitoneal injection at a dose of 50 mg/kg or 500 mg/kg.The survival time and renal fungal burden of mice were observed.Renal histopathology specimens were stained by H-E and PAS staining to assess kidney damage.ResultsThe median survival periods of animals in both ascorbic acid supplementation group and blank control group were 4-5 days.The lgCFU/g values were 8.342, 8.412, 7.350, and 7.764 in experimental groups and 7.134 in the blank control group.Supplementation of ascorbic acid had significant influence on renal fungal burden(P<0.05).Kidney histopathology examination showed renal abscess and renal tubule disorders in mice in all groups, indicating that ascorbic acid supplementation did not alleviate Candida albicans infections.ConclusionAscorbic acid supplementation can not improve the condition of systemic Candida albicans infection in mice, and can even exacerbate the condition.