Objective To observe intermittent pneumatic compression in patients with laparoscopic gastric surgery for lower limb deep venous hemodynamics, and to explore the mechanism. Methods The laparoscopic gastric cancer surgery were randomly divided into the control group and experimental group. And the femoral vein diameter (R), blood flow velocity (V) and blood flow (Q) were determined by color Doppler at different time points during the operation. Results Compared with supine position before pneumoperitoneum, the femoral vein diameter in control group which maintained the first high-pin low position during pneumoperitoneum increased significantly,and the average blood flow velocity and blood flow were both significantly lower (P <0.01); in surgery, with the operation time extension, although the femoral vein diameter had no obvious change (P> 0.05), but the average flow velocity and blood flow were both significantly reduced (P <0.05); After surgery and CO2 gas emission, before postanesthetic revival, which in supine position, femoral vein diameter was thinner (P <0.01), mean flow velocity and blood flow were both significantly increased (P <0.01), but still not reach the level of supine position before pneumoperitoneum (P <0.05). During surgery the experimental group, the femoral vein, the average flow velocity and blood flow were all maintained at a stable state. There were much difference of two groups at each time point hemodynamics. Conclusion Intermittent pneumatic compression is effective in improving, in laparoscopic gastric cancer surgery, the establishment of particular CO2 pneumoperitoneum, and the first high-foot low positon, and prolonged operative time due to femoral vein diameter and thicker, slower blood flow, blood flow decreased reduce postoperative deep vein thrombosis risk.