ObjectiveTo develop and prepare oral rehydration salt powderⅡ (ORSⅡ) effervescent tablets. MethodsTaking the mass/tablet, rigidity, disintegration time, and pressing status as the main indicators, we optimized the formulation and preparation process of the effervescent tablet by single factor test. The character, identification, disintegration time, acidity, and content determination of the tablets were also investigated. ResultsIt was found that the optimized preparation process of the effervescent tablets was to mix the acid part, which was granulated with ethanol, with the base part, and then compressed the mixture. The optimal formula was composed of: NaCl(11.5%), KCl(4.93%), C6H8O7(6.21%), NaHCO3(8.15%), C6H12O6(65.7%), and PEG-6000(3%).The rigidity of the prepared effervescent tablet was 4.5 kg and the disintegration time was 175 s. ConclusionThe formulation of the present product is consistent with the corresponding Chinese Pharmacopoeia monograph, requiring no additional effervescent; the preparation process is simple and the products are stable, and the product my be developed into a new oral rehydration salt formulation.