Abstract:ObjectiveTo investigate the expression of angiopoietinrelated growth factor (AGF) in obese patients and its relationship with body mass index(BMI), waist circumference(WC), waisthip ratio(WHR), blood glucose(FBG), plasma insulin(FINS) levels,and HOMAinsulin resistance index(HOMAIR). MethodsPlasma AGF levels were assayed by ELISA in 40 patients with obesity and 40 normal controls. The relationship of AGF level with BMI, WC, WHR, HbA1c, blood lipids, FBG, FINS, and HOMAIR was also analyzed. ResultsAGF levels in patients with obesity were significantly increased compared with that in the control group ([177.55±74.09] ng/ml vs [122.37±66.91] ng/ml,P<0.05). We also found that AGF level was positively correlated with Triglyceride(TG), FINS and HOMAIR(r=0.325, P<0.05; r=0.451, P<0.01; r=0.483, P<0.01); and was negatively correlated with highdensity lipoprotein cholesterol(HDL, r=-0.529, P<0.01). Multiple regression analysis showed that HDL, BMI and FINS were the factors influencing AGF levels. Binomial Logistic regression analysis indicated that AGF level was positively correlated with obesity after adjusting sex, age, total cholesterol(TC), TG, HDL and lowdensity lipoprotein cholesterol (LDL) (OR>1). Conclusion The change of AGF level is associated with the metabolism disorder in obese patients, and it may also contribute to the pathogenesis of obesity.