单纯性肥胖患者血管形成素相关生长因子的表达及意义
CSTR:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:


Expression of angiopoietin-related growth factor in obese patients and its significance
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的探讨单纯性肥胖患者血管形成素相关生长因子(AGF)表达水平及其与体质指数(BMI)、腰围(WC)、腰臀比(WHR)、空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMAIR)等的关系。方法采用ELISA法检测40例正常人和40例单纯性肥胖患者血浆AGF水平,并分析了AGF水平与BMI、WC、WHR、血脂、糖化血红蛋白(HbA1c)、FBG、FINS和HOMAIR等的关系。结果单纯性肥胖患者AGF水平高于对照组[(177.55±74.09) ng/ml vs (122.37±66.91) ng/ml,P<0.05]; 线性相关分析表明,AGF水平与三酰甘油(TG)、FINS和HOMAIR呈正相关(r=0.325,P<0.05; r=0.451,P<0.01; r=0.483,P<0.01),与HDL呈负相关(r=-0.529,P<0.01)。 以AGF为因变量,性别、年龄、WC、WHR、BMI、TG、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)、HbA1c、FBG、FINS和HOMAIR为自变量,进行多元线性逐步回归分析,结果表明HDL、BMI 和FINS是影响AGF水平的相关因素。二项Logistic回归分析表明,控制性别、年龄、TC、TG、HDL、LDL后AGF水平与单纯性肥胖仍呈显著相关(OR>1)。结论AGF水平的改变与肥胖患者的代谢紊乱有关,并可能参与了单纯性肥胖的发生和发展。

    Abstract:

    ObjectiveTo investigate the expression of angiopoietinrelated growth factor (AGF) in obese patients and its relationship with body mass index(BMI), waist circumference(WC), waisthip ratio(WHR), blood glucose(FBG), plasma insulin(FINS) levels,and HOMAinsulin resistance index(HOMAIR). MethodsPlasma AGF levels were assayed by ELISA in 40 patients with obesity and 40 normal controls. The relationship of AGF level with BMI, WC, WHR, HbA1c, blood lipids, FBG, FINS, and HOMAIR was also analyzed. ResultsAGF levels in patients with obesity were significantly increased compared with that in the control group ([177.55±74.09] ng/ml vs [122.37±66.91] ng/ml,P<0.05). We also found that AGF level was positively correlated with Triglyceride(TG), FINS and HOMAIR(r=0.325, P<0.05; r=0.451, P<0.01; r=0.483, P<0.01); and was negatively correlated with highdensity lipoprotein cholesterol(HDL, r=-0.529, P<0.01). Multiple regression analysis showed that HDL, BMI and FINS were the factors influencing AGF levels. Binomial Logistic regression analysis indicated that AGF level was positively correlated with obesity after adjusting sex, age, total cholesterol(TC), TG, HDL and lowdensity lipoprotein cholesterol (LDL) (OR>1). Conclusion The change of AGF level is associated with the metabolism disorder in obese patients, and it may also contribute to the pathogenesis of obesity.

    参考文献
    相似文献
    引证文献
相关视频

分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2010-10-28
  • 最后修改日期:2010-12-14
  • 录用日期:2010-12-23
  • 在线发布日期: 2011-01-20
  • 出版日期:
文章二维码
重要通知
友情提醒: 近日发现论文正式见刊或网络首发后,有人冒充我刊编辑部名义给作者发邮件,要求添加微信,此系诈骗行为!可致电编辑部核实:021-81870792。
            《海军军医大学学报》编辑部
关闭