[Abstract] Objective To evaluate the preliminary clinical results of Isobar non-fusion internal fixation in treatment of lumbar degeneration disease. Methods From May 2007 to May 2009, 35 cases of lumbar degeneration disease were surgically treated by posterior decompression with Isobar non-fusion internal fixation. The clinical results were assessed by visual analogue scale (VAS) for back and leg pain and Chinese version of Oswestry disability index (ODI), as well as range of motion (ROM) of total lumbar and dynamic fixation segment. Results The follow-up duration was 18 months on average (range，12 to 36 months). All clinical symptoms of the patients were notably improved. One patient experienced a loosened screw at three years after surgery, but no clinical symptom. The mean VAS for back and leg pain was 6.45 before operation, and decreased significantly to 2.12 one year after surgery（P＜0.001）; The mean ODI score was 76.50% before operation, and also recovered significantly to 21.13% one year post-operation(P＜0.001). There were no significant differences in the ROM of total lumbar and dynamic fixation segment before and after operation (P>0.05). Conclusion Preliminary clinical results of Isobar non-fusion internal fixation in treatment of degenerative lumbar disease were satisfying. This kind dynamic stabilization system preserves the motion of fixation segment and provides an alternative for treatment of lumbar degenerative disease.