ObjectiveTo analyze the factors influencing the willingness of receiving colorectal cancer(CRC) screening and barriers of receiving colonoscopy examination among outpatients. MethodsOn-site survey with self-designed colonoscopy questionnaires was performed among consecutive outpatients in a comprehensive hospital. The relationship of the general characteristics of eligible participants with the willingness to receive CRC screening was investigated. The barriers of receiving colonoscopy examination were also investigated. ResultsWe found that 78.4%(439/560) of the outpatients were willing to receive CRC screening. Female sex(P=0.005), low monthly income of the family(P=0.013), and lack of knowledge on CRC(P=0.000) were associated with a low willingness. The main barriers of receiving colonoscopy examination included lack of recommendations from physicians, fear of pain, and fear of complications caused by the examination.ConclusionSex, monthly income of the family, and knowledge on CRC can influence the willingness of outpatients to receive CRC screening; painless colonoscopy may help to promote CRC screening.