ObjectiveTo establish a scoring model for liver cirrhosis disease(SLCD) in experimental rats, so as to provide evidence for early clinical prevention and treatment of liver cirrhosis diseases. MethodsThe liver cirrhosis model was induced in rats by composite factor method. The damages of hepatic tissues and the changes of serological liver function were observed in different phases of the rat liver cirrhosis model. The SLCD formula was obtained using the Matter-Element Analysis method. ResultsThe experimental liver cirrhosis model was successfully established in rats. The experimental rat SLCD and SLCD formula were successfully constructed using the following 6 parameters, the age, total bilirubin, albumin, prealbumin, prothrombin time-international normalized ratio, and serum creatinine. The score was expressed as the R value, which gradually decreased with the aggravation of lesion and fibrosis. R=1: the liver tissue was normal; 0.702≤R＜1: there were inflammatory reaction, focal degeneration and necrosis in the liver; 0.542≤R＜0.702: there was fibroplasia in the liver; 0.352≤R＜0.542: pseudolobules were formed, and it was in the liver cirrhosis stage; and R<0.352: it was in the later stage of liver cirrhosis. ConclusionThe SLCD model can sensitively and accurately display the liver impairment and liver function reserve during experimental liver cirrhosis in rats. It may help the early prevention, diagnosis and treatment of the cirrhosis diseases if relevant clinical evidence is obtained.