ObjectiveTo investigate the effect of norepinephrine on renal injury after resuscitation in a rat model of uncontrolled hemorrhagic shock. MethodsRat model of uncontrolled hemorrhagic shock was established and the model rats were randomly divided into 3 groups, namely, the Sham-operation group, the lactated Ringer’s solution (LR) group, and norepinephrine (NE) group. The mean artery pressure(MAP) were observed in each group 180 min after shock. During resuscitation animals in NE group received norepinephrine (10 μg/\[kg·min\]); the LR group received the same volume of lactated Ringer’s solution. During 70 min resuscitation, lactated Ringer’s solution (40 ml/kg) and half of the shed blood were transfused into animals in NE group and LR group. The blood samples was collected 20 min following half shed blood transfusion for measuring blood urea nitrogen (BUN) and creatinine (Cr). The survival rates were observed 24 h after the resuscitation and the left kidney was evaluated pathologically. ResultsThe serum levels of BUN and Cr in NE group were significantly lower than those in the LR group(P<0.05). And the 24 h survival rate of NE group was significantly higher than that of the LR group (P<0.05). ConclusionNorepinephrine, compared with lactated Ringer’s solution alone, can attenuate renal injury and improve the survival rate of rat models of uncontrolled hemorrhagic shock and resuscitation.