Objective: To explore the epidemiological characteristics of botulism in Ili Kazakh Autonomous Prefecture during the recently 10 years. Methods: The data of botulism in the Ili Kazakh Autonomous Prefecture from 2000 to 2009 were collected and the epidemiological characteristics including seasonal, timely, regional distributions and the responsible foods vary were analyzed. Results: Totally, 89 cases of botulism were involved in this study. The incidence of botulism was significant differences among seasons and years respectively. During the 10-year study period, the number of cases was the greatest in 2006(22.47%), and the number of cases was the lowest in 2001(1.127%)(ⅹ2=53.652, p=0.000) .In addition, the number of botulism was the greatest in winter (55.06%) and the lowest in summer (5.62%)(ⅹ2=52.618, p=0.000). Consumption of home-made bean product which poisoned by Clostridium botulinum bacteria was the most frequent cause of botulism in this study. Conclusion: The key to the control and prevention of botulism is adequate processing and storage of food to destroy spores and prevent their germination and toxin production