ObjectiveTo investigate the infection at surgical sites of laryngectomy and the related risk factors.MethodsWe retrospectively analyzed the clinical data of 96 laryngeal cancer patients, who received laryngectomy in our hospital between Jan. 2006 and Dec. 2010. SPSS 13.0 software was used to analyze the risk factors.ResultsWe found that 15 patients (15.6%) had infection in the surgical sites. ANOVA analysis indicated that the clinical stage, operation time, surgical procedures and preoperative tracheostomy were the risk factors for surgical site infection (P<0.05). Logistic stepwise regression analysis indicated that the clinical stage(OR=0.273) and surgical procedures(OR=8.085) were the independent risk factors.ConclusionImproving the surgical techniques, shortening operation time, and timely and correct management of infection can reduce surgical site infection and pharyngo-cutaneous fistula in laryngeal cancer patients at advanced clinical stages and with extensive operation involvement.