Autosomal dominant polycystic kidney disease(ADPKD) is the most common single gene hereditary kidney disease, which is characterized by formation and persistent growth of renal cysts, damaging the structure and function of the kidneys and finally leading to end stage renal disease. By now there has been no effective therapy in clinical practice. Triptolide, an active diterpene extracted from a traditional Chinese medicine Leigongteng, has anti-inflammation and anti-proliferation effect. Animal studies have shown that triptolide can inhibit cyst formation and protect the renal function, laying a foundation for future clinical use.