ObjectiveTo investigate the protective effect of fenazinel dihydrochloride (FD) against stroke in stroke-prone spontaneously hypertensive rats (SHRSP). MethodsSeven-week old male SHRSP were fed with NaCl 1 g/d to induce stroke. Meanwhile, FD was injected intraperitoneally at 1, 3, and 10 mg/(kg·d). The stroke onset time, survival period after stroke, and neuronic deficit score after stroke were observed. ResultsFD delayed the onset of stroke in SHRSP and prolonged the survival of the animals. Furthermore, low and medium doses FD also improved the neuronal deficit score after stroke. ConclusionOur data suggest that FD has protective effect in SHRSP.