Candida albicans (C.albicans), one of the most commonly-seen opportunistic fungal pathogen, has drawn great public health concern in recent years. C. albicans faces numerous challenges when entering human hosts, including temperature, pH, osmotic stress and oxidative damage. How to adapt to these challenges is critical to the survival and infection ability of C. albicans. This article summarizes the stress response pathways of C. albicans to human host, and it is suggested that studying the stress response pathways may help to find new antifungal targets for C. albicans.