ObjectiveTo observe the influence of intensive control of blood glucose, blood pressure and blood lipid on fasting plasma obestatin level in type 2 diabetes mellitus (T2DM) patients and its correlation with lipid metabolism. MethodsSeventy-two T2DM patients were assigned to four groups according to different treatments. Group A(n=25) received blood glucose (BG) and blood pressure(BP)controlling; group B(n=12) received BG, BP and blood lipid (BL) controlling; group C(n=20) received BG,BP, and BL controlling plus vitamin E administration; and group D(n=15) received BG,BP,BL controlling and compound Danshen dripping pill administration. ResultsFasting obestatin level of group A was significantly lower than those in the other three groups (P<0.01). Fasting obestatin level was negatively correlated with body mass index (BMI), HbAlc, waist to hip ratio (WHR)，total cholesterol(TC), low-density lipoprotein cholesterol (LDL-C), fasting insulin (FIN) and hemeostasis model assessment of insulin resistance (HOMA-IR) (P<0.05), and was positively correlated with high-density lipoprotein cholesterol (HDL-C) (P<0.05). After adjusting age, sex, BMI, WHR, blood glucose, and blood pressure, high level fasting obestatin was correlated with intensified control of blood lipid (P<0.01). ConclusionThe fasting obestatin level is increased in T2DM patients receiving BL control compared with those do not receive, and obestatin level might be associated with lipid metabolism.