ObjectiveTo introduce a new type of China-made bileaflet mechanical prosthetic heart valve(CL-V bileaflet valve)and evaluate its early clinical effectiveness and short-term follow-up outcomes. MethodsTwenty-one patients were included in the present study, with 18 receiving mitral valve replacement and 3 receiving combined mitral and aortic replacement. One AST bileaflet valve(imported) and 23 CL-V bileaflet valves were implanted(21 in mitral position, including one 25M and 20 27M; and 2 in aortic position, including one 23A and one 25A). The ventricular and atrial volume, cardiac function, hemodynamics and hemocompatibility were compared before and one week, 6 months after operation. Valve-related complications were observed during perioperative period and follow-up. ResultsAll the patients were followed up for 6-61 months, with a mean of 19.8 months. There was no early mortality(< 30 d after operation). The patients had stable hemodynamics and satisfactory hemocompatibility early after operation and during short-term follow-up; there were no valve-related complications. ConclusionThe early clinical results and short-term follow-up outcomes of CL-V bileaflet prosthetic valve are satisfactory, with no valve-related complications. The long-term outcome of CL-V bileaflet prosthetic valve needs to be further observed.