ObjectiveTo investigate the change of Dock1 protein expression in non-infarcted myocardium in rats. MethodsExperimental myocardial infarction models were established in 22 SD rats (MI group) and the other 20 rats received sham-operation (Sham group). Eight rats were sacrificed 24 h after operation in each group and another 8 were sacrificed at 12 weeks after operation; the cardiac specimens were collected. Dock1 protein expression was measured by Western blotting analysis in the non-infarcted myocardium of MI group and sham group. ResultsDock1 protein expression was not significantly different in the non-infarcted myocardium between MI group (0.13±0.03) and Sham group (0.10±0.04) at 24 h after operation (P>0.05); 12 weeks after operation, the expression in non-infarcted myocardium of MI group (0.17±0.04) was significantly higher than that of Sham group (0.11±0.05, P<0.05). Dock1 protein expression in non-infarcted myocardium was significantly increased in MI group at 12 weeks after operation compared with those in MI and Sham groups at 24 h after operation (P<0.05). ConclusionThere is Dock1 protein expression in rat’s myocardium, and the expression is significantly increased in the non-infarcted myocardium at 12 weeks after infarction.