ObjectiveTo investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) and its risk factors in physical examination population of Shijiazhuang area, so as to provide evidence for prevention and treatment of NAFLD. MethodsThe medical examination results (January to December in 2010) were obtained from the physical examination center of Hebei Provincial People’s Hospital and Health Service Center of Hedong Community, Shijiazhuang. A total of 20 922 subjects who lived for more than 5 years in Shijiazhuang with complete data were selected for analysis. The prevalence and risk factors of NAFLD in this population were analyzed by univariate and multivariate analysis. ResultsThe prevalence of NAFLD in the present group was 19.18%(4 013/20 922), with that in males being significantly higher than that in females (23.40%\[2 558/10 930\] vs 14.56%\[1 455/9 992\],P<0.001), and there was significant age difference. Multiple logistic regression analysis demonstrated that uric acid (UA), systolic blood pressure (SBP), body mass index (BMI), fasting blood glucose (FBG) and triglyceride (TG) were independent risk factors of NAFLD, and their relative risks increased in order. ConclusionThe physical examination population in Shijiazhuang area has a high prevalence of NAFLD. The prevalence of NAFLD is closely associated with TG, FBG, BMI, SBP and UA.