ObjectiveTo explore the risk factors of in-hospital death of acute myocardial infarction (AMI) patients following percutaneous cornary intervenion (PCI). MethodsWe retrospectively analyzed the clinical data of 275 AMI patients, including the general condition, medical history, admission, intra- and post-operation condition, and complication. The patients underwent PCI in our hospital from January 2009 to September 2011. Logistic regression analysis was used to predict the risk factor of in-hospital death of AMI patients following PCI. ResultsLogistic regression analysis found that female sex (P=0.047, OR=2.91), extensive anterior myocardial infarction (P=0.044, OR=3.07), history of renal insufficiency (P=0.021, OR=7.98), cardiogenic shock (P=0.008, OR=15.71), postoperative thrombolysis in myocardial infarction (TIMI) flow grade ＜3 (P=0.016, OR=5.61), and placement of the intra-aortic balloon pump(IABP, P=0.043,OR=3.49) were associated with an increased risk of in-hospital mortality of AMI patients following PCI. ConclusionFemale sex, extensive anterior myocardial infarction, placement of the IABP, postoperative TIMI flow grade ＜3, history of renal insufficiency, and cardiogenic shock are the risk factors of in-hospital death of AMI patients following PCI.