Objective To establish a scoring formula of liver injury (SFLI) using matter-element analysis, so as to provide evidence for preoperative assessment and treatment of patients with liver cirrhosis diseases.MethodsThe preoperative serum biochemical indicators of liver cirrhosis patients were collected, including albumin (ALB), prealbumin (PA), total bilirubin (TBIL), serum creatine (SCr), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transpeptidase (γ-GT), alkaline phosphatase (ALP), prothrombin time (PT), prothrombin time-international normalized ratio (PT-INR),activated partialthromboplastin time (APTT), and thrombin time (TT). The matter-element analysis was used to establish SFLI, and the results were compared with those of Child liver function system to create SFLI scores. Results An SFLI was successfully established. The scores of cirrhosis extents were expressed as the R value, which gradually decreased with the aggravation of cirrhosis. R=1 represented the normal liver tissue; 0.770≤R<1 represented early liver cirrhosis(compensatory cirrhosis), named SFLI Ⅰ; 0.712≤R<0.770 represented a state between compensatory cirrhosis and decompensated cirrhosis, named SFLI Ⅰ+; 0.629≤R<0.712 represented decompensated cirrhosis combined with ascites, named SFLI Ⅱ; and 0.401≤R<0.629 represented serious decompensated cirrhosis combined with ascites, different degrees of hepatic encephalopathy, and hepatic coma, named SFLI Ⅲ. Conclusion SFLI is a sensitive and accurate formula to demonstrate liver damage and liver function reserve during cirrhosis. It may help the preoperative assessment and treatment of the cirrhosis diseases in clinic.