ObjectiveTo evaluate the reliability and validity of the Chinese version of the anxiety sensitivity index-revised(ASI-CR) among patients with anxiety disorders. MethodsA total of 68 patients with anxiety disorders were interviewed using anxiety sensitivity index-revised (ASI-R), trait anxiety inventory (T-AI), Hamilton anxiety scale (HAMA) and ASI-CR; the reliability and validity of ASI-CR were examined. ResultsInternal consistency of ASI-CR and each factor was 0.77-0.89 and the split-half reliability was 0.67-0.88. The internal correlation coefficient between factors was 0.51-0.65, the correlation coefficient between factors and the total score was 0.83-0.89, and internal correlation coefficient among factors was 0.60-0.90. The correlation coefficient between the total score and factor scores of ASI-CR and total score of ASI-R was 0.76-0.97, and the correlation coefficient between factor scores of ASI-CR and corresponding factor score of ASI-R was 0.78-0.97. The total score and two factor (physical concern and cognitive concern) score of ASI-CR in anxiety patients were significantly higher than the norm (P<0.01). Exploratory factor analysis revealed that the three lower-order ASI-CR factors contributed 65.06% of the total variance. Factor loading of items was 0.51-0.88, but the items were unevenly distributed among factors. Two items had low loading to cognitive concern factor (0.22, 0.48). ConclusionThe ASI-CR displays satisfactory reliability, criterion validity and content validity among anxiety patients, but further research is needed to improve its structural validity.