ObjectiveTo summarize our clinical experience on laparoscopic adrenalectomy for ≥10 cm adrenal tumors. MethodsFrom June 2011 to September 2012, 5 patients received laparoscopic adrenalectomy for ≥10 cm adrenal tumors in our department. The outcomes of patients were observed. The surgical approach, Trocar sites, exposure of operation field, and the management of “dangerous triangle” were all summarized and analyzed. ResultsAll the 5 cases were successfully operated via intraperitoneal approach, with no complications during or after operation. The operation time was 130-270 min (a mean of \[180±65)\] min), the bleeding was 50-300 ml, the anal exhaust time was 2-3 d after operation, and the hospital stay was 5-7 d. Pathological reports included 1 pheochromocytoma, 1 adrenal cortical adenoma, 1 schwannoma, and 2 myelolipoma. ConclusionAdrenal tumor with diameter ≥ 10 cm is no longer a contraindication for performing laparoscopic adrenalectomy when the followings are ensured: highly skilled, accurate surgical approach, comfortable Trocar sites, full exposure of operative field, complete separation of the “three planes”, and safe management of the “dangerous triangle”.