ObjectiveTo investigate the ¹⁸F-FDG PET/CT features of clear cell sarcoma (CCS) of soft tissue. MethodsTen patients with pathologically confirmed CCS were enrolled in the present study. All patients underwent preoperative ¹⁸F-FDG PET/CT scanning, and the image findings and clinical characteristics of the tumors were analyzed. ResultsThe mean maximum standard uptake value (SUV_max) of the primary lesions was 6.52(range, 5-9.6) in the patients. PET/CT revealed lung metastasis in 7 patients, soft tissue metastases in 5, and regional lymph node metastases in 3, with no brain/bone/liver metastases. CT findings showed lung metastases in 6 cases and soft tissue metastasis in one. ConclusionCCS ¹⁸F-FDG PET/CT image lacks specificity, but it can better demonstrate the extent and metastases of CCS, helping the accurate, timely, and more targeted therapy.