Objective To explore the clinical characteristics and coronary angiography findings of Tibetan patients with coronary heart disease living in Tibetan plateau area. Methods A total of 117 cases who underwent coronary angiography and were finally diagnosed as coronary heart disease in our hospital were included in this study from September 2006 to October 2011, and they were divided into Tibetan group (76 cases, 65%) and Han group (41 cases, 35%). The clinical data including blood pressure, glucose, blood lipids, blood uric acid and coronary angiography findings were collected and compared. The characteristics of clinical data and coronary angiography of Tibetan group were analyzed. Results There were no significant differences in body mass index, fasting glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol levels，hypertension, or smoking between the two groups (P>0.05). The onset age, high-density lipoprotein cholesterol and uric acid levels in the Tibetan group was significantly higher than those in the Han group (P<0.05). Single-vessel disease was the dominant type in the Tibetan group, but it also had a larger proportion of complex lesions (three-vessel disease, chronic occlusive lesions, and lesions C). The coronary lesion characteristics were not significantly different between the two groups (P>0.05). Conclusion Hyperuricemia is of great significance for the Tibetan patients with coronary heart disease living in Tibetan plateau area, and the coronary lesions are complex and severe among them.