Objective: To study the clinical features, imaging findings and prognosis of hepatic epithelioid hemangioendothelioma(HEHE)in Eastern Hepatobiliary Surgical Hospital, and to improve the level of recognition and preoperative diagnosis of HEHE. Methods: Clinical data of 15 pathology-confirmed HEHE patients, admitted in our hospital from 1999 to 2010 were collected and analyzed retrospectively. Results: Besides 7 cases of abdominal discomfort, this cohort of HEHE patients does not show common typical manifestations. Laboratory examinations found 8 low ALB/GLB (A/G) cases, 3 mild anemia cases, and 1 high alanine aminotransferase (ALT) case, but no abnormal AFP, CEA or CA19-9 cases. Plain computed tomography (CT) scanning found uneven multiple low-density lesions in most cases, and dynamic enhanced CT scanning demonstrated peripheral enhancement in hepatic arterial (HA) phase and more peripheral enhancement in portal vein (PV) phase, and ring enhancement were detected in delayed phase. Magnetic resonance imaging (MRI) demonstrated low signal intensity and even lower lesion centers in T1-weighted images (T1WI), but slightly high signal intensity lesions and higher lesion centers in T2-weighted images (T2WI). Enhanced MRI scanning showed ring enhancements but no obvious enhanced centers. Lesions were further enhanced in delayed MRI scanning. Prognosis of this cohort: ten of these 15 patients alive nowadays including four cases alive with the tumor. Conclusions: Comprehending the clinical and radiological characteristics of HEHE facilitates the level of recognition and preoperative diagnosis of this disease and promotes surgeons to take active and appropriate surgeries.