Objective To design and prepare a ventricular septal defect (VSD) occluder with bioabsorbable materials and to evaluate its in vitro degradation and mechanical force. Methods A bioresorbable VSD occluder was made of polymeric materials polydioxanone (PDO) monofilament, poly-L-lactic acid (PLA) fabrics and polyglycolic acid(PGA) sutures. Tantalum particles were sewn on the symmetrical parts of the occluder disc as tracers for X-ray, and the end of the right side of the disc was designed with a circular loop for the matched delivery system to clamp and deliver. Mechanical property and the degradation of the occluder were tested in vitro, and the effect of degradation on the mechanical properties and weights of the samples was examined. Results The mechanical properties of the bioresorbable VSD occluder, including the compression/elastic recovery properties, ultimate intensity of circular loop in the right disc,and left disc support force, met the requirements for transcathetering closure of VSD. In vitro degradation experiment demonstrated that the structure and shape of the occluder remained unchanged within eight weeks; PDO wire fracture, disintegration, and incomplete disc structure were observed on the 12^th week. The support force of the left disc increased to 121.7% and 107.8 % of the original ones at the 2^nd week and the 3^rd week, respectively; while the force decreased to 88.6% and 85.3% of the original ones at the 4^th and the 6^th week, respectively. The weight of the occluder decreased by less than 1% within the first 4 weeks, and significantly decreased 6 weeks later. Conclusion The VSD occluder made of biodegradable materials has qualified mechanical force for transcatheter implantation, and it can be used for future animal study.