Objective To retrospectively analyze the intraoperative complications of laparoscopic radical prostatectomy (LRP) during the initial application, so as to analyze the reasons and summarize the experience. Methods The videos of the 60 patients undergoing LRP for prostate cancer in our hospital between January 2010 and November 2012 were reviewed to analyze the intraoperative complications. The patients were the first 20 cases done by 3 surgeons independently. The clinical data, tumor staging, and other related factors were collected for analyzing the reasons for complications of LRP. Results Complications were observed intraoperatively in the 23 patients. The most frequent complications included mistaken suture of bladder catheter (7 cases), open conversion due to intraoperative bleeding (5 cases), residual prostate tissue (5 cases), secondary anastomosis (4 cases), rectal injury (1 case), and specimen missing (1 case). All the events were managed during the operation. The reasons for the complications included unclear anatomical structure, unclear surgical landmark, poor cooperation with assistants, and inconsiderate operative details. Some patients were in the advanced stage, making it difficult to perform the operation. Conclusion The patients with low surgical risk should be chosen for the initial application of LRP, and a stable operation team should be formed. A standard strategy should be formed regarding the equipment selection, surgical procedure, anatomic marking, and manipulation based on viewing the operation; and improvement should be made gradually in practice.