Objective To compare the hemostatic efficacies and exothermic reactions between mesoporous and microporous materials with similar components but different specific surface areas and pore sizes, so as to lay a foundation for developing new first-aid hemostat with mesoporous materials. Methods Totally 15 male pigs were made into femoral artery fatal hemorrhage models and were randomly divided into three average groups (group A, group B and group C). Their hemostatic efficacies and exothermic reactions on the tissues were compared between the three groups (group A was treated with hemostatic mesoporous material HW, group B with microporous material ZSM-5, and group C with standard gauze as control). Results The hemostatic time periods of group A and B were (49.50±3.27) s and (59.50±2.42) s, respectively (P<0.05); standard gauze in group C had failed hemostatic effect. The highest local temperature rose to (42.0± 1.58) ℃in group A, (46.4±1.14)℃ in group B, and (36.8±0.84)℃ in group C, with significant difference found between different groups (P<0.05). Histological test showed that the tissue damage caused by exothermic reaction of mesoporous material HW was slighter than that of microporous material ZSM-5. Conclusion Compared to mesoporous material HW, the microporous material ZSM-5 has more rapid hemostatic efficacies and slighter exothermic reaction, and ZSM-5 is a promising carrier for next generation first-aid hemostatic study.